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| Product Detailes Product namesildenafil CAS No.139755-83-2 MFC22H30N6O4S Molecular Weight474.58 Place of OriginChina AppearanceWhite sildenafil Viagra Powder Specfic1kg/Foil Bag, 25kg/Drum StorageKeep in dark place,Sealed in dry,Room Temperature Water SolubilitySoluble in water at 50mg/ml Purity99% by HPLC Product Description Sildenafil, know as Viagra, is a selective inhibitor of cyclic guanosine monophosphate (CGMP) - specific type 5 phosphodiesterase (PDE5). It has no direct relaxation effect on isolated human sponge, but can enhance the effect of no by inhibiting the decomposition of cGMP PDE5 in sponge. Therefore, sildenafil can be used in the treatment of ED Function & Application Effect of sildenafil on specific sites: sildenafil is a highly selective phosphodiesterase 5 (PDE5) inhibitor. PDE5 is highly expressed in specific sites, but low in other tissues (including platelets, vascular and visceral smooth muscle, skeletal muscle). Sildenafil can selectively inhibit PDE5, enhance nitric oxide (no) - cGMP pathway and increase cGMP level, resulting in relaxation of smooth muscle at specific sites. The experiment showed that the efficacy lasted up to 4 hours, but the response was weaker than that at 2 hours. Response of sildenafil to myocardium: PDE5 does not exist in normal or diseased cardiac conduction tissues, cardiomyocytes, endothelial cells and lymphoid tissues. Therefore, sildenafil (PDE5 inhibitor) has no positive inotropic effect and can not directly affect myocardial systolic function. Effect of sildenafil on cardiac parameters: normal male volunteers took sildenafil 100mg orally without clinically significant ECG changes. Under the monitoring of Swan Ganz catheter, 8 patients with stable ischemic heart disease were injected with sildenafil with a total amount of 40 mg in four times. Results: at rest, the systolic and diastolic blood pressure decreased by 7% and 10% respectively compared with baseline. Resting right atrium, pulmonary artery pressure, pulmonary wedge pressure and cardiac output decreased by 28%, 28%, 20% and 7%, respectively. Although the dose of this intravenous injection was 2-5 times higher than the average peak plasma concentration of sildenafil 100mg in healthy male volunteers, the above hemodynamic response still existed during exercise. Response of sildenafil to blood pressure: a single oral dose of sildenafil 100mg in healthy male patients resulted in a decrease in blood pressure in the lying position (average maximum range 8.4 / 5.5mmhg). The blood pressure decreased most significantly 1-2 hours after taking the medicine, and there was no difference with the placebo group 8 hours after taking the medicine. Sildenafil 25mg, 50mg and 100mg had similar effects on blood pressure, which seemed to have nothing to do with drug dose and blood concentration. Patients taking nitrates at the same time had greater antihypertensive effect. Hypotension (90 / 50mmhg) and nitrates or drugs providing nitrate are strict contraindications for sildenafil. The maximum effect of sildenafil on blood pressure occurred about 1 hour after administration, which was consistent with the peak of drug plasma. Therefore, sexual activity may induce cardiac events at the peak plasma drug concentration of sildenafil. Although the hypotension response caused by sildenafil is mild and transient (blood pressure returns to baseline within 4 hours), the interaction between sildenafil and nitrates can produce significant and longer-term blood pressure reduction. Sildenafil has a short half-life and can be eluted within 24 hours (about 6 half-lives). The American College of Cardiology and the American Heart Association have clearly pointed out that sildenafil is prohibited for those who have used nitrates within 24 hours. Effect of sildenafil on vision: studies have shown that when taking drugs twice the maximum recommended dose, this product has no effect on vision, electroretinogram, intraocular pressure and nipple size. There may be a transient Blue / green color discrimination abnormality. Whether used alone or in combination with aspirin, this product has no effect on human bleeding time. In vitro, this product enhances the anti human platelet aggregation effect of sodium nitroprusside (NO donor). In anesthetized rabbits, the combination of heparin and sildenafil has a superimposed effect on the prolongation of bleeding time, but no similar human study has been carried out. After taking sildenafil 100mg orally, the motility and morphology of sperm were not affected. Our company Certificate Package and shipping How to orderSexual Enhance for sale website:http://www.api-onlinestores.com/sexual-enhance/ |
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